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Publications

82. Peacock, C., Kreplak, L. (2019). Nanomechanical mapping of single collagen fibrils under tension. Nanoscale. in press.
81. Iqbal, S. M. A., Deska-Gauthier, D., Kreplak, L. (2019). Assessing Collagen fibrils molecular damage after a single stretch-release cycle. Soft Matter. in press.
80. Noel, J. A., Kreplak, L., Getangama, N. N., de Bruyn, J. R., White, M. A. (2019). Supercooling and nucleation of fatty acids:influence of thermal history on the behavior of the liquid phase. Journal of Physical Chemistry B. in press.
79. Quigley, A. S., Bancelin, S., Deska-Gauthier, D., Legare, F., Kreplak, L., Veres, S. P. (2018). Combining tensile testing and structural analysis at the single collagen fibril level. Scientific Data (Nature). 5:180229.
78. Cameron, S., Kreplak, L., Rutenberg, A. D. (2018). Polymorphism of stable collagen fibrils. Soft Matter. 14:4772.
77. Bancelin, S., Van Der Kolk, J. N., Quigley, A. S., Pinsard, M., Veres, S. P., Kreplak, L., Ramunno, L., Legare, F. (2018). Gouy phase shift measurement using interferometric Second Harmonic generation. Optics Letters. 43:1958.
76. Quigley, A. S., Bancelin, S., Deska-Gauthier, D., Legare, F., Kreplak, L., Veres, S. P. (2018). In tendons, differing physiological requirements lead to functionally distinct nanostructuresScientific Reports (Nature). 8:4409.
75. O’Neill, C., Kreplak, L., Rueggeberg, F., Labrie, D., Shimokawa, C., Price, R. (2018). Effect of tooth brushing on gloss retention and surface roughness of five bulk-fill resin compositesJournal of Aesthetic and Restorative Dentistry. In press.
74. Kreplak, L., Rutenberg, A. D. (2018). Unlocking Collagen proteolysis with a gentle pullBiophysical Journal. 114:503-4.
73. Chanphai, P., Kreplak, L., Tajmir-Riahi, H. A. (2017). Al cation induces aggregation of serum proteins. Journal of Pharmaceutical and Biomedical Analysis. 141:234-240.
72. Soomro, A., Alsop, A. J., Negishi, A., Kreplak, L., Fudge, D., Kuczmarski, E. R., Goldman, R., Rheinstadter, M. C. (2017). Giant Axonal Neuropathy alters the structure of keratin intermediate filaments in human hair. Journal of the Royal Society Interface. 14:20170123.
71. Baldwin, S. J., Quigley, A. S., Kreplak, L. (2017). Nanomechanics of protein filaments. Physics in Canada. 73(2):1-6.
70. Chanphai, P., Kreplak, L., Tajmir-Riahi, H. A. (2017). Agregation of Trypsin and Trypsin inhibitor with Al cation. Journal of Photochemistry & Photobiology, B: Biology. 169:7-12.
69. Maciel, D., Veres, S. P., Kreuzer, H. J., Kreplak, L. (2017).Quantitative phase measurements of tendon collagen fibresJournal of Biophotonics. 10(1):111-117.
68. Meynell, S. A., Spitzig, A., Edwards, B., Robertson, M. D., Kalliecharan, D., Kreplak, L., Monchesky, T. L. (2016). Structure of MnSi on SiC(0001). Phys. Rev. B. 94(18):184416.
67. Quigley, A. S., Veres, S. P., Kreplak, L. (2016).Bowstring stretching and quantitative imaging of single collagen fibrils via atomic force microscopyPLoS One. 11(9):e0161951.
66. Rutenberg, A. D., Brown, A. I., Kreplak, L. (2016).Uniform spatial distribution of collagen fibril radii within tendon implies local activation of pC-collagen at individual fibrilsPhysical Biology. 13(4):046008.
65. Weatherbee-Martin, N., Xu, L., Hupe, A., Kreplak, L., Fudge, D. S., Liu, X. Q., Rainey, J. K. (2016).Identification of wet-spinning and post-spin stretching methods amenable to recombinant spider Aciniform silkBiomacromolecules. 17(8):2737-46.
64. Baldwin, S. J., Kreplak, L., Lee, J. M. (2016).Characterization via atomic force microscopy of discrete plasticity in collagen fibrils from mechanically overloaded tendons: nano-scale structural changes mimic rope failureJournal of the Mechanical Behavior of Biomedical Materials. 60:356-66.
63. Wiens, R., Findlay, C. R., Baldwin, S. J., Kreplak, L., Lee, J. M., Veres, S. P., Gough, K. M. (2016).High spatial resolution FTIR polarization contrast imaging reveals pre-rupture disorder in damaged tendonFaraday Discussions. 187:555-73.
62. Agudelo, D., Kreplak, L., Tajmir-Riahi, H. A. (2016). tRNA conjugation with chitosan nanoparticles: an AFM imaging study. International Journal of Biological Macromolecules. 85:150-156.
62. Kreplak, L. (2016).Introduction to atomic force microscopy (AFM) in biology. Curr Protoc Protein Sci, 85: Chapter 17: Unit 17.7: 1-21.
61. Agudelo, D., Kreplak, L., Tajmir-Riahi, H. A. (2016). Microscopic and spectroscopic analysis of chitosan-DNA conjugates. Carbohydrate Polymers. 137:207-213.
60. Tajmir-Riahi, H. A., Bekale, L. & Kreplak, L. (2015). Effect of synthetic polymers on tRNA nanoparticle formation. Journal of Nanomedicine Research. 2(3):00031.
59. Froehlich, E., Mandeville, J. S., Bekale, L., Kreplak L., Tajmir-Riahi, H. A. (2015). DNA compaction and particle formation by synthetic polymers: applications in Gene delivery. Journal of Nanomedicine Research. 2(4):00038.
58. Kreplak, L., Rutenberg, A. D. (2014). Lateral exchange smooths the way for vimentin filaments. Biophysical Journal. 107(12):2747-8.
57. Baldwin, S. J., Quigley, A. S., Clegg, C., Kreplak, L. (2014). Nanomechanical mapping of hydrated rat tail tendon collagen I fibrils. Biophysical Journal. 107(8):1794-1801.
56. Brown. A. I., Kreplak, L., Rutenberg, A. D. (2014). An equilibrium double-twist model for the radial structure of collagen fibrils. Soft Matter. 10:8500-11.
55. Daignan, J-M., Chen, R., Mahmoud, K. A., Ma, Y., Hill, I. G., Kreplak, L. (2014). Patterning of Nanocrystalline Cellulose gel phase by electrodissolution of a metallic electrode. PLoS One. 9(6):e99202.
54. Charman, M., Colbourne, T. R., Pietrangelo. A., Kreplak, L. & Ridgway, N. D. (2014). Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival. J Biol Chem. 289(22):15705-17.
53. Negishi, A., Armstrong, C. L., Kreplak, L., Rheinstadter, M. C., Lim, L., Gillis, T. E. & Fudge, D. S. (2012). The production of fibers and films from solubilized hagfish slime thread proteins. Biomacromolecules. 13(11):3475-82.
52. Fortier, P., Suei, S. & Kreplak, L. (2012). Nanoscale strain-hardening of keratin fibres. PLoS One. 7(7): e41814.
51. Suei, S., Plastino, J. & Kreplak, L. (2012). Fascin and VASP synergistically increase the Young’s modulus of actin comet tails. J Struct Biol. 177:40-5.
50. Froehlich, E., Mandeville, J. S., Arnold, D., Kreplak, L. & Tajmir-Riahi, H. A. (2011). The effect of PEG and mPEG-Anthracene on tRNA aggregation and particle formation. Biomacromolecules. 13:282-287.
49. Suei, S., Seyan, R., Noguera, P., Manzi, J., Plastino, J. & Kreplak, L (2011). The mechanical role of VASP in an Arp2/3-complex based motility assay. J Mol Biol. 413:573-83.
48. Froehlich, E., Mandeville, J. S., Arnold, D., Kreplak, L. & Tajmir-Riahi, H. A. (2011). PEG and mPEG Anthracene Induce DNA Condensation and Particle Formation. J Phys Chem B. 115:9873-9.
47. Qin, Z., Chou, C., Kreplak, L. & Buehler, M. J. Structural mechanics and functional properties of intermediate filaments from the atomistic to the cellular scales.(2011).  Chapter 4 in Advances in Cell Mechanics, edited by Shaofan Li and Bohua Sun, published by Springer-Verlag.
46. Froehlich, E., Mandeville, J. S., Kreplak, L. & Tajmir-Riahi, H. A. (2011). Aggregation and particle formation of tRNA by dendrimers. Biomacromolecules. 12:2780-7.
45. Chami, M., Franke, B., Mayans, O. & Kreplak, L. (2011). Assembly of a protein “brush” by end-grafting titin fragments to liposomes. Journal of Bioscience and Bioengineering. 112:178-9.
44. Gullekson, C., Lucas, L., Hewitt, K. & Kreplak, L. (2011). Surface-sensitive Raman spectroscopy of Collagen I fibrilsBiophysical Journal. 100:1837-45.
43. Staple, D., Geisler, M., Hugel, T., Kreplak, L. & Kreuzer, H. J. (2011). Forced desorption of polymers from interfaces. New Journal of Physics. 13:013025.
42. Froehlich, E., Mandeville, J. S., Weinert, C. M., Kreplak, L. & Tajmir-Riahi, H. A. (2011). Bundling and aggregation of DNA by cationic dendrimers. Biomacromolecules, 12:511-7.
41. Brunning, M., Kreplak, L., Leopolseder, S., Muller, S. A., Ringler, P., Duchesne, L., Fernig, D. G., Engel, A., Ucurum-Fotiadis, Z. & Mayans, O. (2010). Bipartite Design of a Self-Fibrillating Protein Copolymer with Nanopatterned Peptide Display Capabilities. Nano Letters. 10(11):4533-7.
40. Kreplak, L. (2010). The contribution of the N- and C- terminal domains to the stretching properties of intermediate filaments. MRS Proceedings. Biological Materials and Structures in Physiologically Extreme Conditions and Disease. 1274:25-9.
39. Kirmse, R., Qin, Z., Weinert, C. M., Hoenger, A., Buehler, M. J. & Kreplak, L. (2010). Plasticity of intermediate filament subunits. PLoS One. 5(8):e12115.
38. Liao, K., Ismail, A. G., Kreplak, L., Schwartz, J. & Hill, I. G. (2010). Designed Organophosphonate Self-Assembled Monolayers Enhance Device Performance of Pentacene-Based Organic Thin-Film Transistors . Adv Mat. 22(28):3081-5.
37. Qin, Z., Buehler, M. J. & Kreplak, L. (2010). A multi-scale approach to understand the mechanobiology of intermediate filaments. J Biomech (Special issue on Mechanobiology). 43:15-22.
36. Goldsbury, C. S., Scheuring, S., Kreplak, L. (2009).Introduction to atomic force microscopy in biology.
Curr Protoc Protein Sci Chapter 17:Unit 17.7: 1-19.
35. Qin, Z., Kreplak, L. & Buehler, M. J. (2009). Hierarchical structure controls nanomechanical properties of vimentin intermediate filaments. PLOS One. 4(10):e7294. (Nanowerk spotlight)
34. Qin, Z., Kreplak, L. & Buehler, M. J. (2009).
Nanomechanical properties of vimentin intermediate filament dimers.
Nanotechnology 20:425101-108. (Nanotechnology release)
33. Colbourne, T. R., Hill, I. G. & Kreplak, L. (2009).
Electric-field induced assembly of vimentin microscaffolds around metallic electrodes.
Biomacromolecules 10:1986-91.
32. Marty, R., N’soukpoe-Kossi, C. N., Carbonneau, D., Kreplak, L. & Tajmir-Riahi, H. (2009).
Structural characterization of cationic lipid-tRNA complexes.
Nuc Acid Res 37(15): 5197-207.
31. Staple, D. B., Loparic, M., Kreuzer, H. J. & Kreplak, L. (2009).
Stretching, unfolding, and deforming protein filaments adsorbed at solid-liquid interfaces using the tip of an atomic force microscope.
Phys Rev Lett 102: 128302
30. Kreplak, L., Nyland, L. R., Contompasis, J. L. & Vigoreaux, J. O. (2009).
Nanomechanics of native thick filaments from indirect flight muscles.
J Mol Biol 386: 1403-10.
29. Nyland, L. R., Palmer, B. M., Chen, Z., Maughan, D. W., Seidman, C.E., Seidman, J. G., Kreplak, L., & Vigoreaux, J. O. (2009). Cardiac myosin binding protein-C is essential for thick-filament stability and flexural rigidity.
Biophys J 96: 3273-80.
28. Marty, R., N’soukpoe-Kossi, N., Carbonneau, D., Weinert, C. M., Kreplak, L. & Tajmir-Riahi, H. (2009).
Structural analysis of DNA complexation with cationic lipids.
Nuc Acid Res 37: 849-57.
27. Kreplak, L. & Bar, H. (2009).
Severe myopathy mutations modify the nanomechanics of desmin intermediate filaments.
J Mol Biol 385: 1043-51.
26. Hill, I. G., Weinert, C. M., Kreplak, L. & van Zyl, B. P. (2009).
Influence of self-assembled monolayer chain length on modified gate dielectric pentacene thin-film transistors.
Appl Phys A 85: 81-87.
25. von Castelmur, E., Marino, M., Svergun, D. I., Kreplak, L., Ucurum-Fotiadis, Z., Konarev, P. V., Urzhumtsev, A., Labeit, D., Labeit, S. & Mayans, O. (2008).
A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain.
PNAS 105: 1186-91.
24. Kreplak, L., Herrmann, H. & Aebi, U. (2008).
Tensile properties of single desmin intermediate filaments.
Biophys J 94: 2790-9.
23. Kreplak*, L., Richter*, K., Aebi, U. & Herrmann H. (2008).
Electron microscopy of intermediate filaments: teaming up with atomic force and confocal laser scanning microscopy. In Introduction to electron microscopy for biologists, ed. Allen, T., Methods in Cell Biology 88: 273-97.
22. Kreplak, L., Wang, H., Aebi, U. & Kong, X. P. (2007).
Atomic force microscopy of mammalian urothelium surface.
J Mol Biol 374: 365-73.
21. Herrmann, H., Bär, H., Kreplak, L., Strelkov, S.V. &  Aebi, U. (2007).
Intermediate filaments: from cell architecture to nanomechanics.
Nat Rev Mol Cell Biol 8: 562-73.
20. Kreplak, L. & Fudge, D.S. (2007).
Biomechanical properties of Intermediate Filaments: from tissues to single filaments and back.
BioEssays 29: 26-35.
19. Sokolova, A. V., Kreplak, L., Svergun, D. I., Herrmann, H., Aebi, U. & Strelkov, S. V. (2006).
Monitoring intermediate filament assembly with small-angle X-ray scattering: molecular architecture of assembly intermediates.
PNAS 103: 16206-16211.
18. Foeger, N., Wiesel, N., Mücke, N., Lotsch, D., Kreplak, L., Aebi, U., Gruenbaum, Y. & Herrmann, H. (2006),
Solubility properties and specific assembly pathways of the B-type lamin from Caenorhabditis elegans.
J Struct Biol 155: 340-350.
17. Bär, H., Mücke, N., Ringler, P., Müller, S. A., Kreplak, L., Katus, H. A., Aebi, U. & Herrmann, H. (2006).
Impact of disease mutations on the assembly of desmin filaments.
J Mol Biol 360: 1031-1042.
16. Guzman, C., Jeney, S., Kreplak, L., Kasas, S., Kulik, A. J., Aebi, U. & Forro, L. (2006).
Exploring the mechanical properties of single vimentin intermediate filaments by atomic force microscopy.
J Mol Biol 360: 623-630.
15. Kreplak, L. & Aebi, U. (2006).
From the polymorphism of amyloid fibrils to their assembly mechanism.
Adv Prot Chem 73: 217-233.
14. Marino, M., Svergun, D. I., Kreplak, L., Konarev, P. V., Maco, B., Labeit, D., Labeit, S. & Mayans, O. (2005).
Poly-Ig tandems from I-band titin share extended domain arrangements irrespective of the distinct features of their modular constituents.
J Mus Res and Cell Mot 10: 1-11.
13. Kreplak, L., Bär, H., Leterrier, J. F., Herrmann, H. & Aebi, U. (2005).
Exploring the mechanical behaviour of single intermediate filaments.
J Mol Biol 354: 569-577.
12. Mücke, N., Kirmse, R. , Wedig, T., Leterrier, J. F. & Kreplak, L. (2005).
Investigation of the morphology of intermediate filaments adsorbed to different solid supports.
J Struct Biol 150: 268-276.
11. Green*, J. D., Kreplak*, L., Goldsbury, C., Li Blatter, X., Stolz, M., Cooper, G. S., Seelig, A., Kistler, J. & Aebi, U. (2004).
Atomic force microscopy suggests lipid loss as the cause for the membrane lesions induced by the amyloidogenic human amylin peptide.
J Mol Biol 342: 877-887.
10. Mücke*, N., Kreplak*, L., Kirmse, R., Wedig, T., Herrmann, H., Aebi, U. & Langowski, J. (2004).
Assessing the flexibility of intermediate filaments by atomic force microscopy.
J Mol Biol 335: 1241-50.
9. Kreplak, L., Doucet, J., Dumas, P. & Briki, F. (2004).
New aspects of the alpha-helix to beta-sheet transition in stretched hard alpha-keratin fibres.
Biophys J 87: 640-7.
8. Kreplak, L., Aebi, U. & Herrmann, H. (2004).
Structural mechanisms underlying the assembly of intermediate filaments.
Experimental Cell Research 301: 77-83.
7. Strelkov, S., Kreplak, L., Herrmann, H. & Aebi, U. (2004).
IF protein Structure determination. In Intermediate filament cytoskeleton, ed. Omary, B. & Coulombe, P. A., Methods in Cell Biology 78: 25-43.
6. Herrmann H., Kreplak, L. & Aebi, U. (2004). Isolation, Characterization and in vitro assembly of intermediate filaments. In Intermediate filament cytoskeleton, ed. Omary, B. & Coulombe, P. A., Methods in Cell Biology 78: 3-24.
5. Kreplak, L., Franbourg, A., Briki, F., Leroy, F., Dalle, D. & Doucet, J. (2002).
A new deformation model of hard alpha-keratin fibres at the nanometre scale: implications for hard alpha-keratin intermediate filament mechanical properties.
Biophys J 82: 2265-74.
4. Kreplak, L., Doucet, J. & Briki, F. (2001).
Unraveling double stranded alpha-helical coiled coils: an x-ray diffraction study on hard alpha-keratin fibers. Biopolymers 58: 526-533.
3. Kreplak, L., Merigoux, C., Briki, F., Flot, D. & Doucet, J. (2001).
Investigation of human hair cuticle structure by microdiffraction: direct observation of cell membrane complex swelling. Biochim Biophys Acta 1547: 268-274.
2. Kreplak, L., Briki, F., Duvault, Y., Doucet, J., Merigoux, C., Leroy, F., Leveque, J. L., Miller, L., Carr, G. L., Williams, G. P. & Dumas, P. (2001).
Profiling lipids across Caucasian and Afro-American hair transverse cuts, using synchrotron infrared microspectrometry. Int J Cosmet Sci 23: 369-374.
1. Briki, F., Busson, B., Kreplak, L., Dumas, P. & Doucet, J. (2000).
Exploring a biological tissue from atomic to macroscopic scale using synchrotron radiation: example of hair.
Cell Mol Biol (Noisy-le-grand) 46: 1005-1016.

* Both authors contributed equally.

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